Total synthesis of (-)-13-oxyingenol and its natural derivative.
نویسندگان
چکیده
Ring functionalization: the total synthesis of a natural derivative of (-)-13-oxyingenol, a potent anti-HIV diterpenoid, is reported. The key steps in this synthesis include a ring-closing olefin metathesis and a Mislow-Evans-type [2,3]-sigmatropic rearrangement. This synthesis provides access to (-)-13-oxyingenol and its natural derivative in 21 steps from a synthetic intermediate previously prepared by Kigoshi and co-workers.
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عنوان ژورنال:
- Angewandte Chemie
دوره 51 20 شماره
صفحات -
تاریخ انتشار 2012